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Risk Factors


Postmortem studies of patients who died in the Warsaw Ghetto during World War II suggested that death from starvation was associated with pulmonary emphysema. To determine whether anorexia nervosa is associated with an increased risk of pulmonary emphysema, Coxson and coworkers examined body mass index (BMI), pulmonary function, and CT of the chest in 21 subjects with anorexia nervosa and 16 control subjects. They found greater CT measurements of emphysema in subjects with anorexia, a correlation between the BMI and the CT measures of emphysema in all subjects examined, and a correlation between diffusing capacity and CT measurements in subjects with anorexia. These results demonstrate emphysema-like changes in the lungs of chronically malnourished subjects.




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Early Emphysema in Patients with Anorexia Nervosa
Harvey O. Coxson, Ida H. T. Chan, John R. Mayo, Julia Hlynsky, Yasutaka Nakano, and C. Laird Birmingham
Am. J. Respir. Crit. Care Med. 170: 748 -752. First published online as doi:10.1164/rccm.200405-651OC [Abstract] [Full text]  

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