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Deep Inspiration
Bronchoprotection induced by deep inspiration protects against the development of airway obstruction induced by spasmogens. To determine whether bronchoprotection induced by deep inspiration is not active against allergic reactions, Pyrgos and coworkers studied 10 subjects with allergic rhinitis. Methacholine induced a 37% decrease in FEV1; when five deep inspirations preceded the methacholine, the decrease in FEV1 was 15%. Inhalation of allergen in the absence of deep inspiration induced a decrease in FEV1 of 25%; when deep inspirations preceded the allergen, the decrease in FEV1 was 29%. The authors conclude that the bronchoprotective action of deep inspirations is absent against allergic reactions.
1 Citation displayed.
Absence of Deep Inspiration–induced Bronchoprotection against Inhaled Allergen
- George Pyrgos, Trisevgeni Kapsali, Solbert Permutt, and Alkis Togias
Am. J. Respir. Crit. Care Med. 167: 1660-1663.
[Abstract]
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